American Journal of Pharmacy and Health Research

Over 100 million deaths were caused by tobacco in the 20th century, over all Tobacco accounts for 1 in 10 deaths in universe. In India about 1 billion cigarettes smokes every day. Nearly 70% of these ten lakh deaths i.e. seven lakh people will die young. A report from “National Representative Case-Control Study of Smoking and Death-06” in India indicates that over 50% of the tobacco deaths will occur in illiterate men or women, with 80% of them residing in rural India. Cigarette Smoking not only contribute to tuberculosis, respiratory disease like COPD development, but also implicated as a major risk factor in many diseases such as pulmonary and cardiovascular pathophysiological conditions. The lungs are the target organ for most of the damage associated with cigarette smoking. As the lungs are primary organ expose to the cigarette smoke, thus cigarette smoking give rise to no. of disorders in respiratory system. Chronic bronchitis and emphysema are Chronic Obstructive Pulmonary Disease (COPD) mainly caused by tobacco smoking. In this present work we plan to control the effect of nicotine present in tobacco in the form of cigarettes mostly by “Removal of Nitrosamines, TAR and Carbonyl carcinogens from the mainstream of cigarette smoke with an aim of reducing toxicity of cigarette smoke by Activated Carbon-Zeolite & Amino Polymer cigarette filter” to treat different disease by different ways as: by removing of nitrosamines and tar from cigarette smoke. Determine the concentration of carcinogens in cigarette smoke after passing through CZC filter, synthesis of different product which reducing effect of nicotine/tobacco and introduce new cigarette filter and considering rethinking the warning “CIGARETTE SMOKING IS INJURIOUS TO HEALTH”. Key words: Tobacco, cigarettes smokes, Chronic Obstructive Pulmonary Disease (COPD), carcinogens, Synthesis, CZC filter etc.

Breast cancer is a leading contributor of cancer-related death among women throughout the world. Exemestane (EXE), a third-generation irreversible aromatase inhibitor, is widely employed for the management of estrogen receptor-positive (ER+) breast cancer. Although the clinical efficacy of EXE is well established, poor aqueous solubility, low oral bioavailability, short plasma half-life, and low permeability limit its therapeutic efficacy. Therefore, the advancement of drug delivery technologies which can improve the pharmacokinetics profile, therapeutic efficacy, and tumor specific accumulation becomes important. In light of the above, the current review summarizes various formulation strategies of EXE including lipid-based nanoparticles, nanoemulsion, lipid nanocapsules, nanoparticles, liposomes, to name a few. However, polymeric mixed micelles are emerging as an effective nanocarrier system because they can improve drug solubilization, enhance cellular uptake, prolong systemic circulation, and facilitate passive tumor targeting. This review discusses the advantages and characterization techniques of polymeric micelles as a drug delivery system with special emphasis on methods of preparation, micellar architecture, and selection of polymers. Furthermore, the review explores polymeric micelles currently approved for clinical usage and undergoing clinical trials for an effective management of cancer. Additionally, incorporating micellar formulations into injectable hydrogels has gained popularity among the research community as it facilitates localised drug delivery and reduces the off target side effects thereby, improve the overall therapeutic efficacy. These advantages underscore the need for EXE encapsulated polymeric micelles integrated in situ hydrogel system to ensure sustained release and maintain therapeutic concentration of EXE to improve the breast cancer treatment. neena.pharma@gndu.ac.in

The synthesis of a series of 2-anilinophenylacetic acids, close analogue of diclofenac, is synthesized and tested for their anti-microbial activity by disk diffusion method. Each 2-anilinophenylacetic acid derivative will be screened for their anti-microbial activity. Syntheses have been carried out following simple methodology in excellent isolated yields. It has been found that compounds AB11, AB12, AB14, AB21, AB24, AB25, AB32, AB34, AB35, AB44, AB45 and AB54 showed the good activity against both of strain comparable to ampicillin and ciprofloxacin was taken as standard at the same concentration whereas all the other compound has showed mild to moderate anti-microbial activity as compared to standard drug. The structure and purity of the original compounds were confirmed by Melting Point, IR, TLC and elemental analysis. Each 2-anilinophenylacetic acid derivative will be screened for their anti-microbial activity. These preliminary results indicate that some of compounds are exhibiting good activity. -------------------------------------------------------------------------------------------------------------------------------------