American Journal of Pharmacy and Health Research

Diabetes, considered a major global public health issue, is often associated with dyslipidemia. Given the limitations of conventional treatments, people are showing increasing interest in medicinal plants. Thus, Rauvolfia vomitoria has several pharmacological properties, including antihypertensive and potentially antidiabetic effects. This study aims to evaluate the effect of repeated oral administration of EARv on the lipid profile over a six-month treatment period. Rauvolfia vomitoria roots were harvested, stripped of their bark, and then processed into an aqueous extract by maceration. Eighty healthy rats were divided into four groups (T, A, B, C) of 20 rats each, with 10 males and 10 females per group. Rats in group T received distilled water, while those in groups A, B, and C received EARv extract at doses of 500, 700 mg/kg body weight (b.w), and 1,000 mg/kg b. w, respectively, administered orally for six months at a rate of 2 mL/100 g b.w daily. Using serum from blood samples collected to measure total cholesterol, HDL cholesterol, and triglycerides. The results show that the aqueous extract of Rauvolfia vomitoria significantly reduced total cholesterol levels in a dose-dependent manner; it also led to an increase in HDL cholesterol levels and a significant reduction in triglycerides. EARv could represent an interesting therapeutic alternative for the management of diabetes and its metabolic complications. Keywords : Aqueous extract of debarked roots- Rauvolfia vomitoria- Lipid profile-Cholesterols -Triglycerides

Background : Cardiovascular diseases (CVDs) remain a major cause of morbidity and mortality worldwide. Drug utilization studies provide valuable information regarding prescribing practices, rational drug use, and medication adherence. Comorbidities such as diabetes mellitus and hypertension often complicate cardiovascular disease management and may influence prescribing patterns. Objective: To evaluate drug utilization patterns and medication adherence among cardiovascular disease patients with associated comorbidities receiving treatment in a private hospital in Tiruvannamalai, Tamil Nadu, India. Methods: A prospective observational study was conducted over six months (February-July 2026) involving 65 adult patients diagnosed with cardiovascular diseases. Data regarding demographics, diagnosis, comorbidities, prescribed medications, dosage regimen, route of administration, laboratory parameters, and medication adherence were collected using a structured case record form. Descriptive statistical methods were used for analysis. Patient adherence was assessed before and after counseling interventions. Results of the 65 patients enrolled, 61.5% were male and 38.5% were female. The majority belonged to the 61-70 years age group. Acute coronary syndrome (41.5%) was the most common cardiovascular condition. Telmisartan (36.9%) was the most frequently prescribed antihypertensive drug, atorvastatin (58.5%) the most commonly prescribed hypolipidemic agent, and clopidogrel (49.2%) the leading antiplatelet medication. Digoxin (41.5%) was the most utilized ionotropic drug, while vildagliptin (30.7%) was the predominant antidiabetic agent among patients with diabetes. Medication adherence improved substantially following counseling, increasing from 59.3% to 84.6%. Conclusion: The study demonstrated the predominance of atorvastatin, clopidogrel, and telmisartan in cardiovascular disease management. Acute coronary syndrome was the most frequently encountered diagnosis. Patient counseling significantly improved medication adherence, emphasizing the importance of pharmacist involvement and rational prescribing in optimizing treatment outcomes among cardiovascular disease patients with comorbidities.

New series of Amino-thiophene dyes 3 (a-g) were synthesized, With growing environmental concerns, developing greener approach for the synthesis of azo dyes is crucial. In present research we describe microwave (MW)-assisted protocol for rapid access to a variety of amino thiophene-azo dyes by coupling amino-thiophenecarboxylate with aromatic amines. After MW-assisted synthesis , Compounds were isolated by precipitation followed by recrystallization to obtain pure azodyes.Then newly synthesized thiophene dyes gave positive solvatochromism so that the absorption bands of the azodye, move towards longer wavelengths as the polarity of the solvent increases. Color plays a significant role in a wide range of industries particularly in printing, pharmaceutical, cosmetic, food, textile.Azo dyes are considered to be easy to use, relatively cheap and to provide clear, strong colours. In India there are approximately 2000 azo dyes available the market. Most of the Artificial dyes are used in the market .They are classified as Azo, Xanthene, Indigo, Tetrazine, Triphenylmethane etc. They are one of the most widely used chromophores in dye chemistry. Azo compounds are the compounds of both natural and manufactured chemicals that contain at least one azo group (N2) in their structure. The atomic groups connected to the nitrogen atoms might be of any organic class, but the commercially relevant azo compounds, ,Which account for more than half of all commercial dyes, contain the benzene group or its derivatives as the attached groups. Although azo compounds come in a wide variety, pigments, and dyes are the most popular. Bismarck Brown, the first commercial azo dye, was introduced in 1863.[1-4]The field of heterocyclic azo dyes continues to be dynamic, driven by the need for brighter, more durable, and environmentally friendly dyes. The synthesis and application of heterocyclic azo dyes, especially in textiles,offer significant advantages in terms of color brilliance, fastness, and versatility. The development of novel dyes, including those with antimicrobial properties, is evidence of the constant innovation in this field.[5-6] .Azo compounds have broad fields of applications such as, antifungal, antibacterial [4], anti-inflammatory [5], anticancer and antioxidant [6]. Beside of it, it has many other applications like, coloring fiber [7], printing systems [8], photo electronics [9], analytical, polymer additive [10], optical recording [11] and storage [12], light and weather fastness [13] and resistance to solvents and water [14-16]. Most of theAzo dyes showed positive absorption spectra. [17-19]