ISSN 2321–3647
Sun, 19 Nov 2017

In Vitro Antioxidant and Anti-Inflammatory Activities of pericarp of Teminalia catappa

Bhavani Boddeda2, Deepthi K2, Swathi Putta1*

1.Pharmacology Division, AU College of Pharmaceutical Sciences, Andhra University

2.Vignan Institute of Pharmaceutical Technology, Visakhapatnam.


ABSTRACT

The present study was designed to evaluate the in vitro antioxidant and anti-inflammatory activity of aqueous leaf extract of Teminalia catappa (ALTC).  Antioxidant activity of the ALTC was determined by following some well established methods for free radical scavenging such as superoxide, hydroxyl, hydrogen peroxide, nitric oxide and DPPH radical scavenging activities using ascorbic acid as standard. The anti-inflammatory activity was evaluated by using HRBC membrane stabilization assay and albumin denaturation assay using diclofenac as standard.  Treatment with ALTC showed dose dependent activity against superoxide, hydroxyl, hydrogen peroxide, nitric oxide and DPPH radicals. The ALTC showed significantly stabilization of membrane and denaturation of protein at a concentration range of 100-500µg/ml.  The antioxidant and anti-inflammatory activity of Teminalia catappa might be due to the anthocyanins in pericarp.

Key words: Teminalia catappa, Antioxidant, Anti-inflammatory activity


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