ISSN 2321–3647
Sun, 19 Nov 2017

In Vitro Evaluation of Anti-Inflammatory and Antiarthritic Activity of Citrus Limetta Peel

Desai S*1, Desai A1, Kanzaria S1, Mishra P1, Meshram DB1

1. Pioneer Pharmacy Degree College, Sayajipura, Vadodara-390019


ABSTRACT

The present study aims on assessing the anti arthritic activity using bovine serum albumin and anti-inflammatory activity using human red blood cell membrane stabilization model. Citrus limetta, commonly known as sweet lime, belongs to family Rutaceae. It is a rich source of flavanoid, d-limonene, alkaloids, steroids, volatile oils and polyphenols. Various extracts of sweet lime peel at different concentrations (50, 100, 200, 400 and 800µg/ml) showed the significant ameliorating effect of hypotonic saline induced RBC membrane damage when compared against standard drug aspirin whereas ameliorating effect by inhibiting protein denaturation on bovine serum albumin in vitro model against standard drug diclofenac sodium. Protective effect on heat induced protein denaturation can be used as a tool to study the in vitro anti-arthritic activity whereas protective effect on heat and hypotonic saline-induced erythrocyte lysis is known to be a very good index of anti-inflammatory activity of any agent. The results of the present study revealed that at various concentrations of Citrus limetta peel extracts when subjected to in vitro anti-arthritic and anti-inflammatory activity showed % inhibition to be significant when compared with standard drug. Thus Citrus limetta fruit peel demonstrates a potential anti-inflammatory and anti-arthritic effect which may be attributed to its anti-oxidant property.

Keywords: Citrus limetta, anti-arthritic, anti-inflammatory, sweet lime


[PDF]  Viewed: 33  Downloaded: 25
  • Call for paper
    Call for paper

    American Journal of Pharmacy and Health Research (AJPHR) is a peer-reviewed, monthly official international journal allowing access to abstracts and full-text.

  • Email & SMS Alerts
    Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics
    Article Statastics

    American Journal of Pharmacy and Health Research (AJPHR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission
    Online Submission

    American Journal of Pharmacy and Health Research (AJPHR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter