ISSN 2321–3647
Tue, 26 Sep 2017

Anti Proliferative Effect of Fungal Polysaccharide on Hela and MCF-7 Cell Lines

Akila RM*1, Manavalan R 2, Ravi TK1

1.Department of Pharmaceutical Biotechnology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore

2.Director, RVS College of Pharmaceutical Sciences & RVS Padmavathi Ammal College of Pharmacy, Coimbatore


ABSTRACT

Chitosan (N-acetyl D- glucosamine) is a natural polysaccharide present in crustacean shells, some fungi and yeast. It is a versatile polysaccharide irrespective of its sources. In the present research work, fungal chitosan is characterized for its anti proliferative effect on HeLa and MCF-7 tumour cell lines by MTT assay. The results showed that GI50 of fungal chitosan was found to be 75µg/ml and 80µg/ml on HeLa and MCF-7 cells respectively.

Keywords: Antiproliferative, Fungal chitosan, HeLa cell lines, MCF-7 cell lines, MTT assay 


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