ISSN 2321–3647
Sat, 18 Nov 2017

Response of Single and Double Mutant Forms of Drosophila melanogaster Under Stress of Alphamethrin

P.N. Saxena1*,  Devika Srivastava1, Sanjay Kumar2

1.Dept. of Zoology, School of Life Science, Khandari Campus, Dr. Bhimrao Ambedkar University, Agra- 282001, India

2.Dept. of Zoology, Acharya Narendra Dev College, University of Delhi, New Delhi- 110019, India


Alphamethrin is an important type II pyrethroid, a cyano-derivative that exhibits toxic response in the mutants of Drosophila melanogaster which has been adjudged on the basis of LC50 values. The concentrations to assess LC50 value of alphamethrin were the same for double mutants (sepia ebony and sepia vestigial) and single mutants (ebony, sepia, vestigial). Double mutant (sepia vestigial) have been adjudged most resistant whereas single mutant (sepia), the most susceptible. The observed difference in LC50 among single and double mutants are due to some genetic consequences which include single chromosome with mutation on one arm, two chromosome with mutation on both the arms, distance of mutation site from centromere, nucleotide bases, pigmentation, wing pattern and rate of mutation, effect of pesticide toxicity on cell survival and metabolism.

Keywords : Alphamethrin, LC50, sepia, ebony, vestigial

[PDF]  Viewed: 88  Downloaded: 38
  • Call for paper
    Call for paper

    American Journal of Pharmacy and Health Research (AJPHR) is a peer-reviewed, monthly official international journal allowing access to abstracts and full-text.

  • Email & SMS Alerts
    Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics
    Article Statastics

    American Journal of Pharmacy and Health Research (AJPHR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission
    Online Submission

    American Journal of Pharmacy and Health Research (AJPHR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter