ISSN 2321–3647
Sun, 19 Nov 2017

UV Visible Spectrophotometric Estimation of AntiRetroviral Drugs

C.M.Bhaskar Reddy1*, N.Ananda Kumar Reddy2 L.Maheswara Reddy3

1. Research Scholar ,Dept of Chemistry, Rayalaseema University, Kurnool,AP, India.

2. S.V. Degree  College. Kadapa, kadapa dist,AP, India.

3.YSR Engineering College of Yogi Vemana University,Proddatur-516360, kadapa dist,AP, India


ABSTRACT

A new spectrophotometric method has been developed for the estimation of antiretroviral drugs namely Efavirenz and Emtricitabine in bulk and tablet dosage form. Efavirenz shows maximum absorbance at 256nm and Emtricitabine at 298nm in presence of solvent chloroform and phosphate buffer of pH 7.4.  The Beer’s law is obeyed in the concentration range of 4-28 μg/ mL for Efavirenz and 2-20 μg/ mL for Emtricitabine. The graph of both drugs shows a straight line with correlation coefficient of 0.9970 for Efavirenz and   0 .9910 for Emtricitabine. The assay method of both drugs was validated by of accuracy and precision of the proposed method. The results are validated as per the directions of International conference on Harmonization.

Keywords: Efavirez, Emtricitabine, UV spectrophotometry, Beer’s law, validation, Tablet Analysis.


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