ISSN 2321–3647
Sat, 18 Nov 2017

Monitoring Efficacy of Therapeutic for Rotavirus Diarrhea Hospitalizations in Yemen based on WHO Guideline

Mohammed Amood AL-Kamarany 1,2 *, Lina Al-Areqi 3 , Abulatif Mujally 3 , Fawzya Alkarshy 3

1. Department of Pharmacy Practice,  Faculty of Clinical Pharmacy, and Tropical Medicine Center,  Hodeidah University, Hodeidah City, Yemen

2.Tihama Foundation for Medical Pharmaceutical Studies & Research, Hodeidah City , Yemen

3.The Yemeni-Swedish Hospital ,  Taiz City , Yemen


ABSTRACT

To assess the efficacy of therapeutic on Rotavirus diarrheal hospitalizations among children < 5 years of age   based on world health organization (WHO) guideline. Based on a longitudinal observational study, 1027 fecal samples were collected from children (less than 5 years), suffering from diarrhea attended at the Yemeni Swedish hospital (YSH) in Taiz , Yemen from January 2009  to December 2012 .  Rotavirus infection was detected by re – validated enzyme linkage immunosorbent assay (ELISA) on stool specimens of children. The treatment course consists of  two methods, namely, intravenous rehydration fluid therapy  (IV) for inpatient and oral rehydration fluid  therapy (OR) for outpatient with treatment of the major  symptoms, namely,  fever and vomiting based on anti – pyretic and anti – emetic if necessary . The efficacy of therapy quality outcomes was assessed clinically and reported. Firstly, the results of re - validated  ELISA method were precise to each analyte with percent relative standard deviation (RSD %) of intra-assay and inter – assay (< 5.0 %). Furthermore, the interval of accuracy for the method exhibited well recovery value of 93 - 100 % and the coefficient correlation (R2) value was  0.99 as a good linear method for Rotavirus infection. Secondly ,  A total of  581  out of  1027  (56.57 %) patients were admitted as inpatients for IV  fluid  therapy  ,  while  446  (43.43 %) were seen in the outpatient ward  receiving  OR  fluid  therapy . The recovery of patients was 98.10 % for IV and 98.43 % for OR, statistically, that was not significantly different (p> 0.05) . In conclusion , A successful   Rotavirus  treatment guidelines in Yemen will rely upon best sustained diagnosis by application Good Laboratory Practice (GLP)  which is clear in specific  – precise , reliable and  accurate method to detect the virus  and the best efficacy of therapy by Good Clinical Practice (GCP) which is clear in treatment  of  Rotavirus diarrhea which protects against dehydration by fluid therapy .

Keywords: Rotavirus, Monitor, Therapy, Diarrhea, Validation, ELISA 


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