ISSN 2321–3647
Sun, 19 Nov 2017

Formulation and Design of Sustained Release Matrix Tablets of Lamivudine: Combination of Chitosan and HPMC

Harekrishna Roy 1,*, Bhabani Shankar Nayak2

1.Research Scholar, Biju Patnaik University of Technology, Rourkela, Odisha, India

2.Department of Pharmaceutics, Jeypore College of Pharmacy, Rondapalli, Koraput, Odisha, India


The current paper was a shot to style a sustained unharness dosage kind victimisation varied grades of hydrophilic polymers, Hypromellose or Hydroxy- propyl alkyl radical polysaccharide (HPMC K15M, HPMC K100M) and Chitosan additionally incorporated as rate retarding material. Laboratory scale batches of Six tablet formulations were ready by wet granulation technique (Low shear). Micromeritic properties of the granules were evaluated before compression. Tablets were characterized as crushing strength, friability, weight variation, thickness, Drug content or assay and evaluated for in-vitro unharness pattern for fifteen unit of time victimisation Phosphate buffer of suitable pH at 37±0.5°C. Results and discussion: The results obtained discovered that HPMC K15M, Chitosan and Ethylcellulose at an acceptable concentration formulation (F6) was able to sustain the drug unharness for fifteen hours and followed Higuchi pattern similar Fickian diffusion. moreover production validation scale batches were designed supported laboratory scale best batch and charged for stability testing. it had been found that every one parameters were at intervals the limit of acceptance. There was no chemical interaction found between the drug and excipients throughout FT-IR and DSC study thought of in the present investigation. therefore it may be over that combinely polymers at an acceptable concentration will effectively be formulate to sustain the drug unharness.

Keywords: Lamivudine, Chitosan, Higuchi, Validation, Drug content.

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