ISSN 2321–3647
Tue, 26 Sep 2017

Protective Effects of Some Antioxidants on Mosquito Repellent (Bioallethrin)-Induced Toxicity in Infant Rats

Ufuk Mercan Yucel1, Orhan Yilmaz2 *

1.Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Yuzuncu Yil, Van, Turkey

2.Department of Pharmaceutical Toxicology, Faculty of Pharmacy, University of Yuzuncu Yil, Van, Turkey


ABSTRACT

The aim of the present study was to investigate the potential toxic effects of bioallethrin-based Mosquito-Repellents (MR) in non-adult rats as well as to ascertain whether the antioxidant substances such as Vitamin C and Vitamin E + Selenium  have any roles in preventing such toxic effects or not. 100 rat pups were divided into four study groups (each group consists of 25 rat pups) as Group I (control), Group II (bioallethrin), Group III (Vit C+ bioallethrin) and Group IV (Vit E+selenium+bioallethrin).  The animals in Group II, III, IV were exposed to the vapor of heated tablets including 4.2% bioallethrin 8 hours/day for a period of ninety days in a room with a volume of 23 m3. Vit C was added at a concentration of 500 mg/L to the fresh drinking water of animals in Group III. Vit E+Selenium combination was administered intraperitonally to the animals in Group IV once weekly at a dose of 50 mg/kg. According to the results, it was determined that antioxidants, particularly combination of Vitamin E+selenium administration, may be beneficial at preventing toxic effects of bioalletrin in rat pups. As a conclusion, when bioallethrin based- MR is used, Vit E+Selenium combination can be advised to prevent the effects of bioallethrin.

Keywords : Mosquito repellent, Bioallethrin, Toxicity, Vitamin C, Vitamin E, Selenium


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