ISSN 2321–3647
Tue, 26 Sep 2017

Evaluation of In Vitro Antioxidant Activity of Various Extracts of Aerial Parts of Chomelia asiatica (Linn)

Abdul Hameed Thayyil2, A. Kottai Muthu1* and Mohammed Ibrahim2

1.Department of Pharmacy, Annamalai University, Annamalai Nagar-608 002, India.

2.Nizam Institute of Pharmacy & Research centre, Near Ramoji Film City, Deshmukhi, Hyderabad, A.P., India.


ABSTRACT

The study was designed to examine the in-vitro antioxidant activities of various extracts of aerial parts of Chomelia asiatica. The antioxidant activity was evaluated by total antioxidant  activity, FRAP  with reference standard ascorbate respectively and estimate the amount of total flavonoids. The ethyl acetate extract of Chomelia asiatica was found to more effective in the total antioxidant activity. The IC50 of the ethyl acetate extract of Chomelia asiatica and ascorbate were found to be 260µg/ml and 480µg/ml respectively. An IC50 value was found that ethyl acetate extract of Chomelia asiatica is more effective in scavenging superoxide radical than that of methanol and petroleum ether extract. But when compare to the all the three extracts with ascorbate (standard), the ethyl acetate extract of the Chomelia asiatica showed the similar result. In addition, the ethyl acetate extract of Chomelia asiatica was found to contain a noticeable amount of total flavonoids, which play a major role in controlling antioxidants.  It is concluded that a aerial parts of ethyl acetate extract of Chomelia asiatica, which contains large amounts of flavonoids compounds, exhibits high antioxidant and free radical scavenging activities. These in vitro assays indicate that this plant extracts is a significant source of natural antioxidant, which might be helpful in preventing the progress of various oxidative stresses.

Keywords: Aerial parts of Chomelia asiatica, total antioxidant, FRAP, total flavonoids.


[PDF]  Viewed: 439  Downloaded: 83
  • Call for paper
    Call for paper

    American Journal of Pharmacy and Health Research (AJPHR) is a peer-reviewed, monthly official international journal allowing access to abstracts and full-text.

  • Email & SMS Alerts
    Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics
    Article Statastics

    American Journal of Pharmacy and Health Research (AJPHR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission
    Online Submission

    American Journal of Pharmacy and Health Research (AJPHR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter