ISSN 2321–3647
Sat, 18 Nov 2017

The Anticancer and Radiosensitizing Activities of EOG (Echitamidine-N-Oxide-19--Β-D-Glucopyranoside) Isolated From The Stem Bark Extract of Alstonia Scholaris

D.Subba Reddy*

Department of Pharmacology, Nirmala College of Pharmacy, Atmakuru(v), Mangalagiri(M),Guntur-522503.


ABSTRACT

The anticancer and radiosensitizing activities of EOG (Echitamidine-N-Oxide-19-o-β-D-Glucopyranoside) isolated from the stem bark extract of Alstonia scholaris were studied in Swiss mice transplanted with Ehrlich ascites carcinoma (EAC) exposed to various doses of g-radiation.  Intraperitoneal administration of 0.5, 1, 2, 4, 6, 8, 10 or 12 mg/kg body weight EOG in animals transplanted with EAC tumor resulted in a dose dependent rise in tumor regression and increase in the average survival as well as mean survival time. The highest number of tumor free survivors were observed in the group receiving 10 mg/kg EOG at the end of 120 days. The administration of 0.5, 1, 2, 4, 6, 8, 10, 12 mg/kg body weight EOG in tumor bearing mice exposed to 6 Gy g-radiation caused EOG dose dependent regression of the tumors when compared to 6 Gy alone and the maximum effect was found in animals receiving 6 mg/kg. Intraperitoneal administration of 6 mg/kg EOG into EAC mice before exposure to 0, 1, 2, 4, 6 or 8 Gy hemi body g-radiation showed an irradiation dose dependent elevation in the tumor free survivors and a maximum number of survivor up to 120 days was observed for 6 Gy irradiation. This led to increase in the average survival and mean survival time by 31 days when compared to 6 Gy irradiation alone.

Keywords: Echitamidine-N-Oxide-Glucopyranoside(EOG), EAC, Survival studies, Radiosensitization study , Irradiation.


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