ISSN 2321–3647
Tue, 26 Sep 2017

Study of analgesic and Anti-inflammatory activity of of Murraya koenigii on albino wistar rats

V. Sandhya1, D. Vijay Anand Raju1, M. Vineel Chandra1, M. Muralidhar reddy1,  Bolay Bhattacharya1*

1.Geethanjali College of Pharmacy, Hyderabad, India


ABSTRACT

Murraya koenigii (Linn) is a plant of the Rutaceae family, well known in India as curry leaves. In the present study, evaluation of physicochemical characteristics; preliminary phytochemical parameters and pharmacological activities of methanol extract of dried leaves of Murraya koenigii Linn has been carried out. The preliminary phytochemical studies of the methanol extract of the leaves showed the presence of various phytochemical constituents such as alkaloids, tannins, flavonoids, steroids and saponins. . The aim of the present study was carried out with the objective of phytochemical screening and to evaluate the antiinflammatory, analgesic activity methanol extract of Murraya koenigii Linn Extract was studied for antiinflammatory activity by using carrageenan-induced hind paw edema in albino rats and the mean increase in paw volume and % inhibition in paw volume were measured plethysmometrically at different time intervals after carrageenan (1% w/v) injection. Extract was also evaluated for analgesic activity using Eddy's hot plate method and acetic acid-induced writhing method in albino rats. The methanol extract showed significant (P < 0.001) reduction in the carrageenan -induced paw edema and analgesic activity evidenced by increase in the reaction time by eddy's hot plate method and significantly reduced (P<0.001) acetic acid induced writhing. The methanol extract showed antiinflammatory and analgesic effect in dose dependent manner when compared with the control and standard drug, diclofenac sodium (10mg/kg, p.o). These inhibitions were statistically significant (P < 0.01). Thus our investigation suggests a potential benefit of Murraya koenigii Linn in treating conditions associated with inflammatory pain.

Keywords: Murraya koenigii, Analgesic activity, Eddy's hot plate, Plethysmometrically, Acetic acid induced writhing


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