ISSN 2321–3647
Sun, 19 Nov 2017

Formulation and Evaluation of Ophthalmic Preparations Containing Econazole Nitrate-Cyclodextrin Complexes

Abd El-Gawad H. Abd El-Gawad1*, Osama A. Soliman1, Marwa S. El-Dahan1, Saeed A. S. Al-Zuhairy1

1.Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, 35516, Mansoura, Egypt


ABSTRACT

Improvement of ocular delivery systems properties remains a major challenge to achieve a continued therapeutic effect of drugs. The aim of the present study was to improve the solubility, dissolution rate and hence the ocular bioavailability of econazole nitrate (EC). To achieve this goal, econazole nitrate was complexed with β-cyclodextrin (β-CyD) and hydroxypropyl-β-cyclodextrin (HP-β-CyD) using co-precipitation method. The influence of different CyDs on EC complexation was investigated by different methods as fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD). The present work includes the preparation of eye gels and ocuserts containing econazole nitrate-cyclodextrins complexes using different polymers. Physicochemical properties (pH, viscosity, uniformity of drug content, in-vitro release) of the preparations were studied by the appropriate methods. The obtained results revealed that, EC solubility increased as a function of CyDs concentration. All formulations possessed uniform drug content with pH and viscosity compatible with the eye. In-vitro release data of ophthalmic formulations showed a sustained release with the diffusion-controlled mechanism (Higuchi model). Ocular bioavailability of EC-CyD complexes from the selected formulations was significantly (p<0.05) improved compared to that of the drug alone. Collectively, the improvement of the solubility, dissolution rate and ocular bioavailability of EC was more pronounced with HP-β-CyD.

Keywords: Econazole nitrate; cyclodextrins; complexation; ophthalmic preparations; ocular bioavailability.


[PDF]  Viewed: 1056  Downloaded: 224
  • Call for paper
    Call for paper

    American Journal of Pharmacy and Health Research (AJPHR) is a peer-reviewed, monthly official international journal allowing access to abstracts and full-text.

  • Email & SMS Alerts
    Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics
    Article Statastics

    American Journal of Pharmacy and Health Research (AJPHR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission
    Online Submission

    American Journal of Pharmacy and Health Research (AJPHR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter