ISSN 2321–3647
Sun, 19 Nov 2017

Development and Evaluation of Push Pull Osmotic System of Isoxsuprine Hydrochloride

Vikrant Suryavanshi*, Deeliprao Derle

1.MVP’s Collage of Pharmacy, Gangapur Road, Nasik 422002


ABSTRACT

The aim of present study was to design and evaluate push pull osmotic pump-based drug delivery system for controlled release of Isoxsuprine hydrochloride for peripheral and cerebral vasodilation. Core tablets were prepared by direct Compression method. Effects of different variables like amount of osmogen, orifice size, coating thickness and dissolution media were studied on release profile. It observed that the combination of PEO 100000 and PEO 300000 give the desired drug release. On increasing the amount of osmogen, the release of drug was found to be increased. On comparison of f2 value no significant effect of pH of dissolution medium, agitation rate was observed but it was observed that the coating thickness decrease it shows the faster drug release and increase in orifice size also increases the drug release.  It was concluded that the osmotic pump tablets could provide more prolonged and controlled release that may result in an improved therapeutic efficacy and patient compliance.

Keywords: Push Pull Osmotic Pumps, Zero order, Isoxsuprine Hydrochloride, Controlled release, Semipermeable Membrane, Cellulose Acetate, Polyethylene Oxide


[PDF]  Viewed: 394  Downloaded: 66
  • Call for paper
    Call for paper

    American Journal of Pharmacy and Health Research (AJPHR) is a peer-reviewed, monthly official international journal allowing access to abstracts and full-text.

  • Email & SMS Alerts
    Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics
    Article Statastics

    American Journal of Pharmacy and Health Research (AJPHR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission
    Online Submission

    American Journal of Pharmacy and Health Research (AJPHR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter