ISSN 2321–3647
Sun, 19 Nov 2017

The Study of Biochemical Parameters And Histopathological Changes In Liver of Albino Rats To Find out The Effect of Extract of Sechium edule Roots Against Paracetamol Induced Hepatic Damages

Bapi Ray Sarkar 1*, Biplab Kumar Dey 1, Mr. Kamal Sharma 1

1.Institute of Pharmacy, Assam down town University, Panikhaiti, Guwahati, Assam, India, Pin- 781026


ABSTRACT

The present study was conducted to evaluate the hepatoprotective activity of Ethanolic extract of Sechium edule against paracetamol induced liver damage in rats. The Ethanolic extract of Sechium edule (300mg/kg & 600mg/kg) was administered orally to the animals with hepatotoxicity induced by single dose of Paracetamol (2gm/kg). Silymarin (25mg/kg) was given as reference standard. All the test drugs were administered orally by suspending in 0.5% Carboxy methyl cellulose (CMC) solution. The Ethanolic extract of leaves of plant Sechium edule in the doses of 300mg/kg, 600mg/kg body wt, reduced the levels of serum SGPT, SGOT, ALP and Total bilirubin and increased the Total protein level significantly. In the histopathological studies of the liver section of rats showed the significant recovery with the Ethanolic extract of Sechium edule when compared with Control group and Paracetamol treated group.

Keywords: Sechium edule, Paracetamol, Hepatoprotetive, Bilirubin.


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