ISSN 2321–3647
Sun, 24 Sep 2017

Effect of Aurum Metallicum on Adjuvant Induced Arthritis in Albino Rats

Prabhakar Raosaheb Patil1*, Rohit Dixit1, Sanappa Ramabhimaiah1, Rajesh Chigatanahalla Subramanya1, Sudha Madhuri1, Abhay Mane2

1 Navodaya Medical College, Raichur.

2 Smt Kashibai Navale Medical College, Pune.


ABSTRACT

Aurum metallicum is the homeopathic preparation of gold. The present study was done to evaluate whether Aurum metallicum is having any anti-rheumatic activity. Arthritis was induced by injecting 0.1ml of Complete Freund’s Adjuvant in left paw of each rat. Aurum metallicum at three dilutions (6, 30 and 200 cH), distilled water and Diclofenac sodium (5mg/Kg) were given daily for 16 consecutive days to the treatment groups, control group and reference group respectively. Treatment started from day 8th day after Complete Freund’s Adjuvant injection. Mean Paw volumes (Primary and Secondary), Thymus weight, Spleen weight and Total body weight were noted after 21 days of Complete Freund’s adjuvant administration. Arthritis index was on 21st day post Complete Freund’s adjuvant injection. The Aurum metallicum at the dilution of 6cH showed decrease in mean paw volume on 21st day post Complete Freund’s Adjuvant administration (P<0.01). Aurum metallicum at dilution 6cH and 30 cH showed less weight gain in thymus gland and spleen compared to control (P<0.01, and P<0.05 respectively). Arthritis index was reduced Aurum metallicum at 6 cH. Aurum metallicum has anti-arthritic activity at dilution of 6cH as shown by various parameters discussed above.

Keywords: Knee, Complete Freund’s Adjuant, Arthritis index, Nanoparticles, Gold, DMARDs.


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