ISSN 2321–3647
Sun, 19 Nov 2017

Identification and Management of Steven Johnson Syndrome Induced Due to Cefixime and Ofloxacin in A Systemic Lupus Erythematosus Patient: A Case Report

Walli Mohammed1*, Samreen Afroz1, Sushanta Kr. Das1, V. Uma Maheswara Rao1

1. Department of Pharm. D, CMR College of Pharmacy, Kandlakoya (V), Hyderabad - 501401, Telangana State, India.


Cefixime and Ofloxacin is one of the common antibiotic combination used in India. Though antibiotic combination therapy can possess with higher complications but useful in various conditions. Cefixime and Ofloxacin induced Steven Johnson Syndrome is common in patients and can be easily identified but situations turns opposite when same complication developed in a patient with Systemic Lupus Erythematosus because, the complication in both the conditions mimic each other therefore, careful examination with supported various laboratory data and past medical/medication history helps proper identification of such conditions. Management of Steven Johnson Syndrome requires prompt withdrawal of suspected/offended drug along with supportive therapy which includes; fluid & electrolyte replacement, systemic and topical corticosteroids, topical anesthetics and antiseptic mouth washes.

Keywords: Cefixime, Ofloxacin, Steven Johnson Syndrome, Systemic Lupus Erythematosus Identification and Management.

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