ISSN 2321–3647
Sat, 18 Nov 2017

Is ischemia Modified Albumin is a Marker in Preeclampsia? A Case Control Study in Kolar Population-a South West of India

C D Dayanand*1, Vanishree Bambrana2, Nagarjuna Sivaraj3, Mary Shobha Rani Inala4

1. Department of Biochemistry, Head of Allied Health Sciences, Sri Devaraj Urs Medical College, SDUAHER, Kolar, Karnataka, 563101.

2. Department of Biochemistry, Sri Devaraj Urs Medical College, Sri Devaraj Urs academy of higher education and research, Kolar, Karnataka 563101.

3. Sri Devaraj Urs academy of higher education and research, Kolar, Karnataka 563 101.

4. Department of Allied Health Sciences, Sri Devaraj Urs academy of higher education and research, Kolar, Karnataka 563101.


ABSTRACT

Preeclampsia is a syndrome occurring in pregnancy that affects multiple systemic functions and leads to increased maternal and foetal morbidity as well as mortality. Ischemia Modified Albumin is a well-known marker of cardiac Ischemia. We aimed to test the hypothesis that variation in maternal serum Ischemia Modified Albumin (IMA) in preeclampsia during pre and post labour within 48 hours. A Longitudinal observational study was conducted between June 20 to April 2013in subjects with normal pregnancy (n=30), women with preeclampsia (n=30) and non-pregnant women (n=30) to evaluate the levels of IMA. The women studied were in 20-35thweeks of gestation visited obstetrics clinic in R.L. Jalappa hospital& Research center, Kolar, in a southern state of India. We estimated the maternal serum IMA levels before and after the delivery within 48 hours by using Albumin Cobalt Binding procedure. The results obtained were analysed by using Microsoft Excel 2013 and Quick R.  p value < 0.05 is considered as statistically significant. The Median IMA level in the preeclampsia group before delivery 1.071ABSU [inter quartile range (IQR) 0.453-1.708ABSU] and the same within 48hrs after delivery 1.013ABSU [inter quartile range (IQR) 0.526-1.774 ABSU)] was significantly lower (p<0.02) than in normal pregnant group before delivery 0.328 ABSU [inter quartile range (IQR) 0.154-0.592 ABSU] and the same within 48hrs after delivery 0.570ABSU [inter quartile range (IQR) 0.060-0.751 ABSU. However, a significant increase in IMA concentrations (p<0.001) when compared to non-pregnant women 0.101 ABSU [inter quartile range (IQR) 0.049-0.358ABSU]. In vivo modification of albumin at the amino terminal residues loose in vitro Cobalt (Co (II)) binding ability. The trend of Modified albumin as IMA in preeclampsia shows the gradual increase after the delivery within 48 hrs. However the levels of IMA in normal pregnancy show a tenfold increase than the non-pregnant women.

Keywords: Ischemia Modified Albumin, Intrauterine Hypoxia, Preeclampsia.


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