ISSN 2321–3647
Sat, 18 Nov 2017

Development and Evaluation of Fast Dissolving Tablets of Valsartan Using Different Binders

Kanav Midha1*, Manju Nagpal1, Garima Singh1, Hudson C Polonini2, Sandeep Arora1

1. Chitkara University, Chandigarh-Patiala National Highway, Rajpura 140401.

2. Federal University of Santa Catarina, Brazil.


ABSTRACT

The aim of present work was to develop fast dissolving tablets of Valsartan by direct compression method using different binders such as acacia, sucrose, starch, gelatin, hydroxypropyl methylcellulose (HPMC) H7509, and Polyvinyl-pyrrolidone (PVP). During the compression of tablets, binders keep the composition of these fast dissolving tablets together. The right selection of binder or combination of these is essential to maintain the integrity and stability of the tablet. The prepared tablets were evaluated for parameters such as hardness, friability, drug content, weight variation, wetting time, water absorption ratio, in-vitro disintegration time, in vitro dissolution studies and stability studies. The study reveals that formulations prepared by direct compression (F5) exhibits better dissolution (90.57%) with lowest disintegration time (40 seconds) containing sucrose as binding agent.

Keywords: Fast dissolving tablets, Superdisintegrants, Direct Compression, Disintegration


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