ISSN 2321–3647
Sun, 24 Sep 2017

Nano delivery Systems of Resveratrol to Enhance its Oral Bioavailability

Kanav Midha1*, Manju Nagpal1, Hudson C Polonini2, Sandeep Arora1

1. Chitkara University, Chandigarh-Patiala National Highway, Rajpura.

2. Federal University of Santa Catarina, Brazil.


ABSTRACT

Resveratrol is a polyphenol found in grapes and red wines. Interest in this polyphenol has increased due to its pharmacological cardio- and neuroprotective, chemopreventive, and antiaging effects, among others. Nevertheless, its pharmacokinetic properties are less favorable, since the compound has poor bioavailability, low water solubility, and is chemically unstable. To overcome these problems, we developed two novel resveratrol nanodelivery systems based on lipid nanoparticles to enhance resveratrol’s oral bioavailability for further use in medicines, supplements, and nutraceuticals. Solid lipid nanoparticles (SLNs) and nano structured lipid carriers (NLCs) loaded with resveratrol were successfully produced by homogenization and ultrasonication technique. These were completely characterized for particle size, zeta potential, DSC and TEM, to evaluate the quality of the developed resveratrol-loaded nanoparticles. The in vitro release studies showed that both the nanosystems are highly stable system allowing sustained and controlled release after uptake.

Keywords: Nanosystems, solid lipid nanoparticles, ultrasonication, homogenization.

 


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