ISSN 2321–3647
Sun, 19 Nov 2017

Preparation and Evaluation of Clotrimazole Loaded Nanosponges Containing Vaginal Gels

P. Suresh Kumar1*, N.Hematheerthani1J.VijayaRatna2, V.Saikishore3

1. Nova College of Pharmaceutical Education and Research, Hyderabad.

2. College of Pharmaceutical Sciences, Andhra University, Vizag.

3. Bapatla college of Pharmacy, Bapatla.


ABSTRACT

The rationale of the present work is to design a vaginal gel formulation with mucoadhesive properties to ensure longer residence at the infection site, providing a favourable release profile for the antifungal drug clotrimazole with the help of β-cyclodextrin nanosponges. Hence efforts were made to prepare clotrimazole loaded nanosponges containing vaginal gels using polymers like hydroxy propyl methyl cellulose (HPMC), sodium carboxy methyl cellulose (NaCMC), methyl cellulose (MC) and carbopol. The gel formulations were prepared with a view to improve permeability of drug. The prepared gel were evaluated for pH, Viscosity, Spreadability, Extrudability, Mucoadhesive time and In vitro diffusion study. The gel formulations can be graded in the following order with respect to the rates of diffusion of drug from them: (HPMC) < (MC) <(NaCMC < (Carbopol). The correlation coefficient values (r) revealed that the diffusion profiles follows zero order kinetics and the mechanism of drug release was governed by peppas model. The diffusion exponent of release profiles (slope) has a value of (n>0.5), which indicates non fickian diffusion. It was found that the clotrimazole loaded nano sponges containing gels prepared with HPMC showed good extrudability, homogeneity, spreadability and required diffusion rate in comparison with other formulations and was selected as suitable candidate to be delivered through vaginal route at controlled rate.

Keywords: Clotrimazole, β-cyclodextrin, nanosponges, diffusion rate.


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