ISSN 2321–3647
Sat, 18 Nov 2017

Anti-Arthritic Effect of Boswellia Serrata in Arthritic Patients in a Secondary Care Hospital

B. Arul1*, R. Kothai1, Syed Rahisuddin1, B. Jayakar1

1. Department of Pharmacy Practice, Vinayaka Mission’s College of Pharmacy, Yercaud Main Road, Salem - 636008, Tamilnadu.


ABSTRACT

Rheumatoid arthritis (RA) is an autoimmune disease that results in a chronic, systemic inflammatory disorder that may affect many tissues and organs, but principally attacks flexible (synovial) joints. It can be a disabling and painful condition, which can lead to substantial loss of functioning and mobility if not adequately treated. Conventional medicine treats rheumatoid arthritis with steroids and other immunosuppressive medications, most of which are toxic when used long-term. Patients who are dependent on them are now likely to respond to herbal products. Boswellia serrata (Shallaki) is mentioned as a pain remedy in ancient Sanskrit texts dating back thousands of years. The herb is recommended in treating rheumatoid arthritis, osteoarthritis, gout, joint pain, skeletal muscle pain and back pain. B-boswellic acid, its 11-keto derivative and their acetates are the important constituents derived from the resin which are responsible for the anti-inflammatory activity of Shallaki. Shallaki improves the blood supply to the joints and restores the integrity of blood vessels destroyed by spasms. Degradation of glycosaminoglycans, which leads to articular damage and cartilage breakdown, is a common condition in patients on nonsteroidal anti-inflammatory drugs (NSAIDs). Shallaki significantly reduces the degradation of glycosaminoglycans and protects the joints. So, in this present study an attempt was made to study the anti-arthritic efficacy of the Shallaki in patients by observational study. A total 65 patients who suffered with severe rheumatic pain with joint dysfunction and clinical decline during the treatment with Shallaki capsule was examined. Rheumatoid factor (RF) and Erythrocyte sedimentation rate (ESR) were measured to evaluate the anti arthritic activity. Results of the present study revealed that the percent reduction of ESR found with Shallaki capsule is more than the combination of steroids and NSAIDs. The significant effects were observed with percent reduction of RF by Shallaki capsule then steroids and NSAIDs. The triple combination posses quite more effects than observed with individuals. From the above data it was concluded that the Shallaki capsule posses the ulcer protective anti inflammatory and anti arthritic effects in patients of arthritis, whereby, it is not possible to propose a same effects by conventional steroids and NSAIDs. Shallaki capsule reduces glycosaminoglycan degradation and increases maintenance of collagen which inhibits the progress of arthritis in lower doses.

Keywords: Arthritis, Boswellia serrata, NSAIDs.


[PDF]  Viewed: 697  Downloaded: 119
  • Call for paper
    Call for paper

    American Journal of Pharmacy and Health Research (AJPHR) is a peer-reviewed, monthly official international journal allowing access to abstracts and full-text.

  • Email & SMS Alerts
    Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics
    Article Statastics

    American Journal of Pharmacy and Health Research (AJPHR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission
    Online Submission

    American Journal of Pharmacy and Health Research (AJPHR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter