ISSN 2321–3647
Sat, 18 Nov 2017

Preparation and Characterization of Silver Nanoparticles Incorporated Chitosan Hydrogel Sheet for Wound Healing

J. Sindhu*, J. Sundaraseelan

1. Department of Pharmaceutics, Sri Padmavathi School of Pharmacy, Tiruchanoor, Andhra Pradesh, India.


The present work aimed to develop a novel chitosan–PVA-based hydrogel sheet which forms an immobilizing matrix for silver nanoparticles (AgNPs). Silver nanoparticles were prepared by chemical reduction method. Silver nitrate was taken as the metal precursor and tri-sodium citrate as a reducing agent. These AgNPs were incorporated in to chitosan-PVA hydrogels in different concentrations (1%, 2%, 4% and 6%) to form F1, F2, F3 and F4 formulations respectively. The prepared chitosan and silver nanoparticle composite hydrogel sheets were characterized using U.V, FTIR, water absorption studies, SEM and Anti-microbial studies. The data shows the average diameter of AgNPs is in the range of 60-70 nm and is roughly spherical in shape. The AgNPs incorporated hydrogel sheets were bactericidal against Escherichia Coli (gram positive) and staphylococcus aureus (gram negative) and it showed good antibacterial effect by disc diffusion method. These results suggested that AgNPs incorporated chitosan hydrogel sheet could be a promising candidate for wound dressing applications.

Keywords: Chitosan, Hydrogel, Silver Nanoparticles, Chemical reduction.

[PDF]  Viewed: 800  Downloaded: 138
  • Call for paper
    Call for paper

    American Journal of Pharmacy and Health Research (AJPHR) is a peer-reviewed, monthly official international journal allowing access to abstracts and full-text.

  • Email & SMS Alerts
    Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics
    Article Statastics

    American Journal of Pharmacy and Health Research (AJPHR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission
    Online Submission

    American Journal of Pharmacy and Health Research (AJPHR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter