ISSN 2321–3647
Sun, 19 Nov 2017

Synthesis, Characterization and Biological Evaluation of Novel Substituted 1,3,4-Oxadiazoles and 1,3,4-Thiadiazoles as Anthelmintic Agents

Prabhat Kumar Upadhyay1*, Pradeep Mishra1

1. Institute of Pharmaceutical Research, GLA University, Mathura- 281406, (U.P.) India


The aim of our study was to review on design, synthesis and various pharmacological activities associated with the substituted oxadiazoles and thaidiazoles. Series of 5-(2-Amino-4,5,6,7- tetrahydro-1-benzothien-3-yl) N-substituted 1,3,4-thaidiazole-2-amines(Va-e)  were prepared from thiosemicarbazides (IIIa-e) by cyclization using phosphoric acid and 5-(2-Amino-4,5,6,7- tetrahydro-1-benzothien-3-yl) N-substituted 1,3,4-oxadiazole-2-amines (IVa-e) were preparedfrom substituted thiosemicarbazides (IIIa-e)by treating with Iodine &NaOH. Compounds (IIIa-e) were prepared by treating 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbohydrazide (II) with isothiocyanates.Compound II was synthesized by treating ethyl 2-amino-4,5,6,7-tetra hydrobenzeno [b]thiophene-3-carboxylate (I) with hydrazinehydrate. Compound I was prepared by one pot synthesis fromcyclohexanone,sulphur,ethylcyanoacetate in presence of diethyl amine. All the synthesized compounds were charecterized by IR, NMR and mass spectrometry and screened for and in vitro-antihelmintic activity. They showed  moderate to good anthelmintic activity against Indian earthworm Pheretimaposthuma.

Keywords: 1,3,4-Oxadiazole, 1,3,4-Thaidiazole; Antihelmintic activity.

[PDF]  Viewed: 689  Downloaded: 100
  • Call for paper
    Call for paper

    American Journal of Pharmacy and Health Research (AJPHR) is a peer-reviewed, monthly official international journal allowing access to abstracts and full-text.

  • Email & SMS Alerts
    Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics
    Article Statastics

    American Journal of Pharmacy and Health Research (AJPHR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission
    Online Submission

    American Journal of Pharmacy and Health Research (AJPHR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter