ISSN 2321–3647
Sun, 19 Nov 2017

Hypoglycemic Activity of Gloriosa Superba on STZ Induced Diabetic Rats

Geeta R.Basaiye1*, Sugandha G.Chaudhari1, Neetu R1, Rajendra Patil1, Mukeshkumar M. Chavan1, Vikram Bafna1

1. Department of Pharmacology Dr.Hiranandani College of pharmacy.Ulhasnagar-03, Mumbai.


ABSTRACT

Gloriosa Superba is an Indian medicinal plant demonstrated to expect multiple pharmacology effects. In light of traditional claim of the plant in treatment of diabetes, the present study was carried out to evaluate the hypoglycemic actvity of the plant in STZ induced diabetics rats. The diabetic’s rats were given ethanolic extract of Gloriosa superb (EEGS) (50mg/kg, 100mg/kg, and 200mg/kg) and metformin (180mg/kg) for 28days.The effect of both treatments on body weight and blood glucose were assessed. Three doses of extract and metformin show significant hypoglycemic actvity in acute, sub-acute study. Body wt. of extract and metformin treated rats were maintained during the study period where as body wt. of untreated rats had gone down. The result obtained from the study scientifically proved the folkloric use of Gloriosa Superba as Hypoglycemic agent. Thus the plant can be key contributor in treatment of diabetes.

Keywords: Diabetes Mellitus, Gloriosa Superba, Metformin, STZ.


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