ISSN 2321–3647
Sun, 19 Nov 2017

UV-Spectrophtometric Assay Method for the Assay of Tolterodine in Pure and Formulations

Siva Shankar Rao G1, P.S.Sarat1, Ramachandran D1*

1. Department of Chemistry, Acharya Nagarjuna University,Guntur,AP,India.


A simple, cost effective and reproducible UV-spectrophotometric method has been developed and validated for the assay of Tolterodine in pure and dosage forms. This assay is based on measurement of absorption at maximum wavelength of 282nm. Beer’s law of this proposed method was obeyed in the concentration range of 60-120μg/mL with regression equation of y = 0.0068x-0.0117 and with correlation coefficient of 0.9988 respectively. The percentage recovery of tolterodine ranged from 99.93- 100.37 in pharmaceutical dosage form. The results of the analysis for linearity, accuracy (recovery), precision and specificity were validated statistically and by recovery studies in accordance with ICH norms.

Keywords: Tolterodine, UV-Spectrophotometry.

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