ISSN 2321–3647
Sun, 24 Sep 2017

Preparation of Suitable Nanofibre by Blending of Natural and Synthetic Polymer for Tissue Engineering Applications

R.Sridhar Skylab1*, N.Surya Prabha1, P.Tamilselvi2, T.S.Natrajan3

1. Biomedical Engineering Division, Department of ECE, CEG Campus, Anna University, Chennai, Tamilnadu 600025, India.

2. Department of Anatomy, Sathiyabama Dental College, Chennai, Tamilnadu 600119, India.

3. Department of Physics, Indian Institute of Technology Madras, Chennai, Tamilnadu 600039, India.


ABSTRACT

Tissue engineering field is an interdisciplinary field that has endeavoured to utilize a variety of processing methods with synthetic and natural polymers for various applications like scaffold preparation, drug delivery, wound healing and nanoparticle preparation. Blending of Polymers is one of the most effective method for providing new, desirable biocomposites for tissue engineering applications. Polymer exhibits a variety of physical and chemical properties from the constituent polymer. In this project preparation of chitosan and polyethylene oxide nanofibrewas performed by the process of electrospinning method. Chitosan is a natural polymer obtained from shell of shellfish and it has novel properties like biocompatibility, biodegradability, and antibacterial. Polyethylene oxide is a synthetic polymer which is also reported to be non toxic and highly degradable polymer. Blending ratio of these two polymers was varied to obtain uniform nanofibres. The blended polymer had been characterized by SEM, UTM and FTIR studies and their toxicity was studied by MTT assay and staining method.

Keywords:Nanofibres, Natural and Synthetic, Polymer, Tissue Engineering.


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