ISSN 2321–3647
Sun, 19 Nov 2017

Chronotherapeutic Formulation of Levetiracetam for the Treatment of Nocturnal Epilepsy

Akila RM*, Nitin Kaushik

1. Department of Pharmaceutics, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore-641044, Tamilnadu, India.


ABSTRACT

In general, as a subclass of epilepsy, nocturnal epilepsy intensify one of the major problems of epilepsy as it is less likely witnessed than daytime epilepsy and therefore it is very difficult to diagnose and characterize and this results in sleep disruption which can cause daytime somnolence and concentration difficulty. So, the present research work was aimed to formulate a programmable pulsatile press coated tablets of levetiracetam inorder to achieve chronotherapy for nocturnal epilepsy. The core tablets containing levetiracetam were prepared by direct compression method and press coated with HPMC K100M and MCC. The prepared pulsatile tablets were evaluated for in-vitro release to get desirable pulsatile release of drug after a lag time of 2.5 h. Drug-excipients compatibility study by IR spectrophotometer showed that all the excipients were compatible with the drug. The stability study was carried out for the desired optimized formulation for a period of 3months and showed insignificant difference.

Keywords: Nocturnal epilepsy, Chronotherapy, Circadian Rhythm, Lag time, Levetiracetam.


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