ISSN 2321–3647
Sun, 24 Sep 2017

Simple novel UV-spectroscopic method for estimation of Ezetimibe in tablet dosage form

R.P. Kabra*1, S. C. Kadam1, V. B. Mane1, S. S. Kadam1, C. G. Mamde2

1.Department of Pharmaceutical Chemistry, Satara College of Pharmacy, Degaon, Satara, Maharashtra, India.415004

2.Okasa Pharma Pvt. Ltd. Satara , Maharashtra, India.415004


ABSTRACT

A simple, accurate and precise UV-spectrophotometric method was developed for determination of Ezetimibe in bulk and tablet dosage form. This method based on determination of ezetimibe in ethanol: acetic acid (90:10) at 252 nm. Regression analysis of Beer’s plots showed good correlation in concentration range of 2- 20 µg/ml for Ezetimibe. The % recovery was between 100.9 to 102.32% indicating high degree of accuracy of the proposed methods. The results of the analysis were validated statistically and recovery studies were carried out as per ICH guidelines.

Keywords: Ezetimibe, UV-Spectroscopic method, recovery studies


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