ISSN 2321–3647
Tue, 17 Oct 2017

An Acute Oral Toxicity Study of Seeds of Spermacoce Hispida Linn, in Albino Wistar Mice as Per OECD Guidelines 425

Dhevi R*1, Elango V2, Gayathri K3, Mohamed Shabi M4

1. Research Scholar, Department of Siddha medicine, Tamil University, TN, India.

2. Assistant Professor, Department of Siddha medicine, Tamil University, TN, India.

3. Assistant Professor, Department of Biochemistry, Vels University, TN, India.

4. Lecturer, Department of Pharmacology, Asia Metropoliton University, Malaysia


ABSTRACT

Acute toxicity refers to those adverse effects occurring following oral or dermal administration of a single dose of a substance, or multiple doses given within 24 hours, or an inhalation exposure of 4 hours. Acute toxicity studies in animals are usually necessary for any pharmaceutical intended for human use and are useful in choosing doses for repeat-dose studies, providing preliminary identification of target organs of toxicity, and, occasionally, revealing delayed toxicity. The present study has been undertaken to study the adverse or hazardous effects of hydro alcoholic extract of seeds of Spermacoce hispida Linn, in Albino wistar mice as per OECD guidelines 425. Single dose of spermacoce hispida seed extract at the dose of 500, 1000 and 2000mg/kg b.wt were administered to albino wistar mice. No mortality or any clinical sign change was observed during the entire study period. The LD50 and maximum tolerable dose value of the extract was greater than 2000mg/kg body weight.

Keywords: Spermacoce hispida, Acute Toxicity, OECD Guidelines 425, Lethality (LD50).


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