ISSN 2321–3647
Sun, 24 Sep 2017

Preparation and Evaluation of Etodolac Loaded Eudragit Rs 100 Microcapsules using Quality by Design Approach

Anuja Vishnu Patil1*, Kishorkumar Balkrishna Burade1, Rameshwari Parmeshwar Darade1

1. Department of Biopharmaceutics, Government College of Pharmacy,  Karad-415124.


ABSTRACT

The objective of the current study was to design and optimize Etodolac loaded Eudragit RS 100 microcapsules using solvent evaporation method. Quality by design approach was implemented for development of Etodolac microcapsules using I-Optimal RSM design. Based on initial risk assessment and preliminary study, two independent variables, Drug: Eudragit RS 100 ratio and stirring speed were selected for Design of Experimentation (DoE) to see effect on critical quality attributes (CQAs); entrapment efficiency and particle size. The prepared Etodolac loaded Eudragit RS 100 microcapsules were characterized for particle size, entrapment efficiency, in-vitro dissolution study, DSC, XRD and SEM. Acceptance criteria for CQAs were considered as particle size in the range of 22-200 µm and entrapment efficiency in the range of 72.86-97.25 %, which generated the design space with combination of selected critical parameters leading to the acceptable operating ranges for formulating microcapsules with respect to desired Target Quality Product Profile (TQPP). The obtained Etodolac loaded Eudragit RS 100 microcapsules were spherical in shape, having better entrapment efficiency and sustained drug release profile. Validation of model was carried out by comparing experimental values with predicted value of optimized formulation. Optimized formulations within design space were capable of sustaining drug release for about 22 hours and were expected to reduce dosing frequency thus reducing side effects associated with therapy.

Keywords: Etodolac, Eudragit RS 100, Quality by design, entrapment efficiency, particle size.

 


[PDF]  Viewed: 943  Downloaded: 93
  • Call for paper
    Call for paper

    American Journal of Pharmacy and Health Research (AJPHR) is a peer-reviewed, monthly official international journal allowing access to abstracts and full-text.

  • Email & SMS Alerts
    Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics
    Article Statastics

    American Journal of Pharmacy and Health Research (AJPHR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission
    Online Submission

    American Journal of Pharmacy and Health Research (AJPHR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter