ISSN 2321–3647
Sat, 18 Nov 2017

Effects of Nigella sativa seed oil as adjuvant therapy for type 2 diabetes mellitus (DM) patients

Attia SA1, Abdel-Salam MM2 , Bazan NS3, Badary OA4, El-Damassy HE5

1.Sarah Adel Attia, B. Pharm. Sci., Faculty of Pharmacy, October 6th University

2.Dr. Mona Mohamed Abde- Salam, MD, Lecturer of Internal Medicine and Endocrinology, Faculty of Medicine, Ain Shams University.

3.Dr. Naglaa  samir  Bazan, Ph.D, Fellow Clinical Pharmacy, Critical Care Medicine Department, Cairo University Hospitals.

4.Prof.Dr. Osama Ahmed Badary, Ph.D., Professor of Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University.

5.Prof. Dr. Hussein El-Sayed El-Damasy, MD, Professor of Diabetes and Endocrinology, Faculty of Medicine, Ain Shams University.


ABSTRACT

To evaluate the effectiveness of Nigella Sativa seed oil as adjuvant therapy for type 2 diabetes mellitus (DM) patients. Forty three Egyptian patients with type 2 DM on oral hypoglycemic drugs were enrolled in this study. Patients were divided into two groups. Group I comprised patients on their standard antidiabetic drug regimen, and group II comprised patients on their standard antidiabetic drug regimen in addition to Nigella sativa seed oil. All patients were followed for 6 months. Parameters to evaluate glycemic control included Fasting Blood Glucose (FBG), Post Prandial Blood Glucose (PPBG) and Glycated Haemoglobin (HbA1c). Glycemic control parameters were measured at the beginning of study, after 3 months of therapy and after 6 months of therapy. To evaluate the antioxidant effect of Nigella sativa, superoxide dismutase (SOD) and Glutathione peroxidase (GPx) were measured before therapy and after 6 months of therapy. In addition, serum C-peptide, lipid profile, liver and kidney functions were assessed at the beginning and end of study. Nigella sativa administration for six months significantly improved FBG, PPBG and HbA1c. In addition, SOD and Gpx were significantly increased after six months of treatment with Nigella sativa. Nigella sativa at a dose of 900 mg daily improved glycemic control in type 2 DM patients maintained on oral hypoglycemic drugs. Evaluation of the effect of Nigella sativa as an antioxidant in reducing complications of type 2 DM in further studies is supported by the positive findings of this study on SOD and Gpx.

Keywords: Nigella sativa- Diabetes Mellitus- Oxidative stress- Glycated Haemoglobin


[PDF]  Viewed: 1304  Downloaded: 163
  • Call for paper
    Call for paper

    American Journal of Pharmacy and Health Research (AJPHR) is a peer-reviewed, monthly official international journal allowing access to abstracts and full-text.

  • Email & SMS Alerts
    Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics
    Article Statastics

    American Journal of Pharmacy and Health Research (AJPHR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission
    Online Submission

    American Journal of Pharmacy and Health Research (AJPHR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter