ISSN 2321–3647
Sun, 19 Nov 2017

In vitro Hyperpigmentant activity on the bark of Dalbergia sissoo Roxb.

T. Muthu Lakshmi 1*,  R.Radha1,N. Jayshree 1

1.Department of Pharmacognosy, College of Pharmacy,Madras Medical College, Chennai-03.


ABSTRACT

Vitiligo also known as Leucoderma is caused by the loss of pigment, resulting in irregular pale patches of skin. Vitiligo develops patches of depigmented skin appearing on extremities. The objective of the present study was to evaluate the cytotoxicity and in-vitro melanogenic activity on bark of Dalbergia sissoo Roxb (Fabaceae). The various successive bark  extracts have been individually evaluated for trials of spontaneous melanin content, and cell viability by the MTT assay in murine B16F10 melanoma cells in-vitro. Based on the percentage of cell viability assay, graded concentration of extracts were taken for invitro melanogenic activity. The result indicated that Ethyl acetate extract of bark of Dalbergia sissoo was found to be non-toxic and increased melanin activity as compared to Hexane and Ethanol extracts. From the above result, it can be concluded from this study that the bark of Dalbergia sissoo stimulates B16F10 melanogenesis at very low concentrations. These findings support the folk medicinal use of Dalbergia sissoo on the treatment of hypopigmentation diseases, such as vitiligo.

Keywords: Leucoderma, Dalbergia sissoo, Ethanol.


[PDF]  Viewed: 953  Downloaded: 92
  • Call for paper
    Call for paper

    American Journal of Pharmacy and Health Research (AJPHR) is a peer-reviewed, monthly official international journal allowing access to abstracts and full-text.

  • Email & SMS Alerts
    Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics
    Article Statastics

    American Journal of Pharmacy and Health Research (AJPHR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission
    Online Submission

    American Journal of Pharmacy and Health Research (AJPHR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter