ISSN 2321–3647
Sun, 19 Nov 2017

Synthesis and Biological study of Substituted 1, 2, 4-Triazolines and their acetyl derivatives

Chandrakant Bhaskar*1, Jagannath Makode2, Baliram Berad3,

1. Department of Chemistry,Art’s, Commerce and Science College, Koradi (Nagpur)-441111(MS)

2. Department of Chemistry, Shri Shivaji College of Art’s, Commerce and Science, Akola-444101(MS)

3. Post Graduate Department of Chemistry, RTM Nagpur University, Nagpur-440033. (MS)


ABSTRACT

In the reaction of isoniazid with different aldehydes the respective N1-((un)-substituted benzilidene) isoniazid derivatives were obtained. Further reaction with N1-((un)-substituted benzilidene) isoniazids and hydrazine hydrate yielded dihydroformazans. These dihydroformazans on reaction  with N-phenylisocynodichloride in chloroform medium led to the creation of 1, 2, 4-triazolines. All these 1,2,4-triazolines were further converted into their acetyl derivatives by reacting them with acetic anhydride. The structures of all new compounds were confirmed by using elemental and spectral analysis. All the compounds were screened for their antifungal activities.

Keywords: 1, 2, 4-Triazolines, Dihydroformazans, Synthesis of 1, 2, 4-triazolines.


[PDF]  Viewed: 1217  Downloaded: 152
  • Call for paper
    Call for paper

    American Journal of Pharmacy and Health Research (AJPHR) is a peer-reviewed, monthly official international journal allowing access to abstracts and full-text.

  • Email & SMS Alerts
    Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics
    Article Statastics

    American Journal of Pharmacy and Health Research (AJPHR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission
    Online Submission

    American Journal of Pharmacy and Health Research (AJPHR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter