ISSN 2321–3647
Sun, 19 Nov 2017

Synthesis and Biological study of Substituted 1, 2, 4-Triazolines and their acetyl derivatives

Chandrakant Bhaskar*1, Jagannath Makode2, Baliram Berad3,

1. Department of Chemistry,Art’s, Commerce and Science College, Koradi (Nagpur)-441111(MS)

2. Department of Chemistry, Shri Shivaji College of Art’s, Commerce and Science, Akola-444101(MS)

3. Post Graduate Department of Chemistry, RTM Nagpur University, Nagpur-440033. (MS)


In the reaction of isoniazid with different aldehydes the respective N1-((un)-substituted benzilidene) isoniazid derivatives were obtained. Further reaction with N1-((un)-substituted benzilidene) isoniazids and hydrazine hydrate yielded dihydroformazans. These dihydroformazans on reaction  with N-phenylisocynodichloride in chloroform medium led to the creation of 1, 2, 4-triazolines. All these 1,2,4-triazolines were further converted into their acetyl derivatives by reacting them with acetic anhydride. The structures of all new compounds were confirmed by using elemental and spectral analysis. All the compounds were screened for their antifungal activities.

Keywords: 1, 2, 4-Triazolines, Dihydroformazans, Synthesis of 1, 2, 4-triazolines.

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