ISSN 2321–3647
Sat, 18 Nov 2017

Experimental evaluation of an Ayurvedic drug on dissolution of encrustation

Sahu.M1, Barik.LD2,Shrivastav.SK3, Dwivedi .US4 , Mishra.SP5, Anupam G. Banerjee6

1. Dept.of Pharmaceutics6. Banaras Hindu University,Varanasi-221005


ABSTRACT

Encrustation, a crust or hard coating on the surface of urinary stent & catheter, is developed due to the formation of biofilm caused by super saturation, adherence of micro bacteria and eventually deposition of mucoroteins, ions and crystals. Blockage of the stents & catheters causes reflux of urine thereby increasing renal pressure and ultimately damaging renal parenchymal tissues. El-Faqih et al has reported that encrustation occurs in 76.3% of stents left in place longer than 12 weeks. Urinary pH plays a role in the etiology of Stone formation and also for encrustation. The formation of various types of kidney stones is strongly influenced by urinary pH. An alkaline pH favors the crystallization of calcium- and phosphate-containing stones, whereas acidic urine pH promotes uric acid or cystine stones. pH/pKa of the drug reacted with different crystal forming chemicals on micro (replicated) environment  Drug schedules-Dried  aqueous extract of  Bryophyllum pinnatum and Crataeva nurvala taken for the study. Solubility is a function of pH. Maintenance of neutral pH increases aqueous solubility. pH of  Drug with different crystal forming element was between 7.5 to 7.6 .

Keywords: Encrustation, Stent, catheter, quath extract(dried water extract)

 


[PDF]  Viewed: 900  Downloaded: 95
  • Call for paper
    Call for paper

    American Journal of Pharmacy and Health Research (AJPHR) is a peer-reviewed, monthly official international journal allowing access to abstracts and full-text.

  • Email & SMS Alerts
    Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics
    Article Statastics

    American Journal of Pharmacy and Health Research (AJPHR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission
    Online Submission

    American Journal of Pharmacy and Health Research (AJPHR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter