ISSN 2321–3647
Sat, 18 Nov 2017

Microwave –Assisted Efficient Synthesis of Thiazoles Containing Piperidone- 4-One Moiety as Probes for Antimicrobial Activities

R. Sumathi, S. Syed Shafi*

Department of Chemistry,Thiruvalluvar University,Serkadu, Vellore – 632115, Tamil Nadu.


ABSTRACT

Microwave  assisted organic reaction enhancements (MORE) is a simple, clean, fast, efficient, economic and environment friendly method for the synthesis of 4- piperidones. The aim of this article is to synthesize characterize and evaluate the antimicrobial activity of certain novel thiazole compounds. The synthesized compounds were characterized by elemental analysis and IR, NMR and mass spectral data. All compounds were found to exhibit a fair degree of antimicrobial activity.

Keywords:Piperidine -4-one, thioesemicarbazone, various substituted phenacyl –bromides.


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