ISSN 2321–3647
Sat, 18 Nov 2017

Anti-Atherosclerotic and Lipolytic Property of Polyherbal Formulation

Vedasri R1*, Geetha K2, Uma Maheswara Rao. V3, Vijay R. Chidrawar1, Mounika Talla1, Swathi R1.

1.Department of Pharmacology, CMR College of Pharmacy, Hyderabad, AP, India.

1.Department of Biotechnology, CMR College of Pharmacy, Hyderabad, AP, India.

1.Department of Pharmacognosy, CMR College of Pharmacy, Hyderabad, AP, India.


ABSTRACT

The incidence of coronary heart disease has markedly increased in India over the past few years. Ischemic heart disease, the largest cause of morbidity and mortality in the developed and developing countries today is overwhelmingly contributed by atherosclerosis. The main objective of the study is to evaluate the phytochemical screening of the plants and find out the potency of polyherbal formulation in high fat diet induced atherosclerosis in rats. Terminalia arjuna, Nardostachys jatamansi, Garcinia combogia, Tribulus terrestris, Inula racemosa are ayurvedic medicinal plants used in India to treat several ailments. The present study was aimed at performing pre-clinical studies of a polyherbal formulation prepared from the above mentioned plants in high cholesterol diet induced atherosclerosis in rats. The study highlights the activity of the polyherbal formulation in the treatment of atherosclerosis. 6 groups of male rats containing 5 animals per each group were taken and given 200mg/kg/day, 300mg/kg/day and 400mg/kg/day of hydroalcoholic extract of polyherbal formulation orally for 28 days along with the high cholesterol diet. The experiment showed promising results by significantly decreasing cholesterol, triglycerides, and LDL levels. Significant reduction in serum total cholesterol and increased HDL cholesterol was seen. The extract also showed hepato protective activity. MDA levels were reduced considerably. Our studies indicate that hydro alcoholic extract of plants used in polyherbal formulation exerts potent hypolipidemic effects in atherosclerotic rats which are evident from the histopathological results.

Keywords:  Atherosclerosis, Plaque, Cholesterol, Atherogenic index, Cardiovascular diseases.


[PDF]  Viewed: 842  Downloaded: 105
  • Call for paper
    Call for paper

    American Journal of Pharmacy and Health Research (AJPHR) is a peer-reviewed, monthly official international journal allowing access to abstracts and full-text.

  • Email & SMS Alerts
    Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics
    Article Statastics

    American Journal of Pharmacy and Health Research (AJPHR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission
    Online Submission

    American Journal of Pharmacy and Health Research (AJPHR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter