ISSN 2321–3647
Sun, 19 Nov 2017

Phamacokinetic Evaluation of Microcapsules Containing Fluvastatin Sodium Using Rats

Venkatesh DP*1, Roopa Karki1, Hanumantha Rayappa B1, Divakar Goli1

1.Department of Pharmaceutics, Acharya and B. M Reddy College of Pharmacy, Soldevanahalli, Bangalore, India.


ABSTRACT

Microcapsules containing Fluvastatin Sodium having better drug retaining property. Most suitable for controlled release. Most satisfactory Fluvastatin Sodium microcapsules were subjected to pharmacokinetic evaluation with an objective to evaluate their drug release retarding and rate controlling efficiency in vivo. The rats were used for the in vivo bioavailability study. Ion exchange resins coated microcapsules of Fluvastatin Sodium was prepared by w/o/w emulsification technique. Fluvastatin Sodium release from Indion454 resins coated with eudragit RS100 microcapsules was slow and spread over 24 h. In the in vivo study, the absorption of fluvastatin sodium was slow over longer period of time with a rate constant (Ka) of 1.605 h-1. The mean residence time was observed from 6.5 h. Cmax was found to be 2.24µg/ml, tmax was found to be 6h, AUC was found to be 2.24µg/ml. From pharmacokinetic evaluation, Fluvastatin Sodium from resins coated microcapsules was released and absorbed slowly over longer period of time.

Keywords:  Fluvastatin Sodium, Microcapsules, Pharmacokinetics, controlled release.


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