ISSN 2321–3647
Sun, 19 Nov 2017

A New Validated Stability-Indicating RP-HPLC Assay Method for Pentoxifylline In Bulk Drug

N.Murali Krishna1, S.V.M.Vardhan2 C.Rambabu3

1. Department of Basic humanities, Velagapudi Ramakrishna Siddhartha Engineering College
(Autonomous) Kanuru , Vijayawada

2.Department of Biochemistry, K.U.Dr.MRAR P.G. Centre, Nuzvid, AP, India

3. Department of Chemistry, Acharya Nagarjuna university, Guntur, AP, India.


ABSTRACT

An isocratic reversed phase stability-indicating reverse phase high-performance liquid chromatographic (HPLC) assay method have been developed and validated for the determination of pentoxifylline in bulk drugs. Separation of pentoxifylline from the degradation products was carried out using an Inertsil ODS C18 (250cm x 4.6)mm,5u column  with  mobile phase consisting a mixture of  acetonitrile  and  KH2PO4 buffer (pH 4.0) in the ratio of (60:40v/v). The detection was carried out at wavelength 275nm. The developed method was validated with respect to linearity, accuracy (recovery), precision, system suitability, selectivity prove the stability indicating ability of the method.

Keywords: RP-HPLC, Stability indicating and Pentoxifylline. 


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