ISSN 2321–3647
Sun, 19 Nov 2017

Evaluation of Anti-Obesity Potential of Erythroxylon Monogynum Against High Fat Diet Induced Obesity In Wistar Rats

Rupesh Kanhere1*, Kandula Ravindra Reddy2, Korlakanti Narasimha Jayaveera3, Sadhu Nelson Kumar4, Cuddapa Rajaram4

1. Department of Pharmacology, P. Rami Reddy Memorial College of Pharmacy, Kadapa- 516003, A.P, India.

2. Department of Pharmaceutics, P. Rami Reddy Memorial College of Pharmacy, Kadapa- 516003, A.P, India.

3 International Science-Tech Research Institute, Anantapur – 515 001, A.P, India.

4. Department of Pharmacology, P. Rami Reddy Memorial College of Pharmacy, Kadapa- 516003, A.P, India.


ABSTRACT

Obesity is an abnormal excessive growth of adipose tissue, results from the combined effects of excess energy intake and reduced energy expenditure. Ever growing research in herbal drugs from Indian system of medicine suggests that beneficial effect herbs or its phytoconstitiuents in various ailments since ancient time. Anti obesity potential of chloroform fraction of erythroxylon monogynum (CEM) in high fat diet induced obesity in wistar rats was evaluated.  Female rats were fed with high fat diet for 8 weeks. CEM was administered at a dose of 250 mg/kg, p.o. and 500 mg/kg for last 3 weeks while high fat diet offering. Parameters like body weight, feed consumption were monitored throughout experimental period. On Day 57, various biochemical parameters like serum glucose, serum lipid profile e.g. total cholesterol and triglyceride , HDL-C, LDL-C, VLDL as well as other biochemical parameters like SGOT, SGPT and total protein were estimated.  Effect of treatment on cardiovascular risk factor indicator i.e. atherogenic index was also calculated. Finally effect on vital organs like liver, heart and kidney as well as epididymal fat pad was also recorded. Due to treatment, there was a significant reduction in dose dependant manner in body weight and other elevated biochemical parameters like serum glucose, TG, TC, LDL-C, and VLDL levels. Decreased HDL- C level in HFD fed animals were significantly improved due to treatment of CEM. Atheroginic index as well as relative epididymal fat pad weight was found to be reduced due to CEM treatment.

Keywords: Chloroform fraction, Atheroginic index, Hypolipidemic, Erythroxylon monogynum.


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