ISSN 2321–3647
Sat, 18 Nov 2017

Development and In-Vitro Evaluation of Bilayer Elementary Osmotic Tablet of Verapamil Hydrochoride

Sancheti Vikram Nirmal1*, ChordiyaMayur Ashok2, K. Senthilkumaran3

1. Department of Pharmaceutics, Padmavathi College of Pharmacy & Research Institute, Dharmapuri, Tamil nadu, India.

2. Department of Pharmaceutics, SNJBs SSDJ College of Pharmacy, Chandwad, Nashik, India.

3. Department of Pharmaceutics, K.K. College of Pharmacy, Chennai, India.


ABSTRACT

The purpose of this study was to develop a bilayer elementary osmotic tablet of Verapamil Hydrochloride. The drug candidate selected under the study is Verapamil hydrochloride, a calcium channel blocking agent used in the treatment of angina pectoris, hypertension and cardiac arrhythmia. Verapamil Hydrochloride has a short elimination half-life; this will bring down its dosing frequency to once a day and on the same time make a zero order release system. Tablets were prepared by using controlled release polymers. The formulations were evaluated for pharmacopoeial quality control tests and all the physical parameters evaluated were within the acceptable limits. Formulation B12 was proved to be good drug content, dimensional stability and drug release up to 24 h as compared to the other formulations. Stability studies were carried out on the optimized formulationB12 for period of 3 months at 400C/75 %RH. Finally it was observed that there was no change in physiochemical and physical properties as well as in drug release profile even after storage at 45 °C and 75 % for three months.

Keywords: Verapamil hydrochloride, dimensional stability, elementary osmotic tablet, stability study.


[PDF]  Viewed: 673  Downloaded: 79
  • Call for paper
    Call for paper

    American Journal of Pharmacy and Health Research (AJPHR) is a peer-reviewed, monthly official international journal allowing access to abstracts and full-text.

  • Email & SMS Alerts
    Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics
    Article Statastics

    American Journal of Pharmacy and Health Research (AJPHR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission
    Online Submission

    American Journal of Pharmacy and Health Research (AJPHR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter