ISSN 2321–3647
Sat, 18 Nov 2017

Validated UV-Spectrophotometric Method for the Assay of Voriconazole in Pure and Formulations

B.V.Sreenivasulu1*, C.Rambabu2

1. Department of Biochemistry, Acharya Nagarjuna University,Guntur,AP,India.

2. Department of Chemistry, Acharya Nagarjuna University,Guntur,AP,India.


ABSTRACT

A simple, accurate, cost effective and reproducible UV-Spectrophotometric method has been developed and validated for the estimation of voriconazole in pure and dosage forms. The present UV-spectrophotometric method is based on measurement of absorption at maximum wavelength of 256nm. The Beer’s law of this method was obeyed in the concentration range of 5-30μg/ml with the linear equation of Y = 0.0218x - 0.0029 and correlation coefficient of 0.9996. The percentage recovery of voriconazole ranged from (99.96) in pharmaceutical dosage forms.

Keywords: Voriconazole, UV-Spectrophotometry, Dosage forms.


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