ISSN 2321–3647
Sat, 18 Nov 2017

Novel Oral Drug Delivery System: Fast Dissolving Buccal Films

M. Sri rekha*1, SK. Shaheda Sultana1, K. Mahathi1, P. Parveen1, B. Prathima1, A. Seethadevi1

1. Dept. of pharmaceutics, Hindu college of pharmacy, Guntur, Andhra Pradesh, India.


ABSTRACT

Fast dissolving buccal films is a novel oral drug delivery system offers new possibilities for drug delivery by providing the advantages of oral delivery coupled with the enhanced safety and efficacy of a drug molecule, enhanced onset of action, improved bioavailability by avoiding first pass metabolism and enzymatic degradation in the GI tract and convenience to special patient categories such as pediatrics, geriatrics and bedridden patients who experience difficulties in swallowing the conventional oral dosage form. This delivery system consists of a thin oral film, which is simply placed on the patient’s tongue or any oral mucosal tissue (buccal/sublingual), instantly wet by saliva, rapidly hydrates and adhere onto site of application, where it disintegrates and dissolves to release the medication for oral mucosal absorption. More recently, fast dissolving films are gaining interest as an alternative to fast dissolving tablets to definitely eliminate patient’s fear of chocking and overcome patient impediments. Fast dissolving films are formulated using polymers, plasticizers, sweeteners, flavours and colours. Fast dissolving films were prepared by solvent casting, rolling, extrusion and solid dispersion method. The films evaluated for disintegration, dissolution, tensile strength, thickness, folding endurance and elastic modulus. This article overview the advancements in oral dosage forms, formulation considerations, method of preparation, evaluation, marketed products and it also suggests that this delivery system can be adopted by various pharmaceutical companies in future at large scale.

Keywords: Fast dissolving buccal film, polymer, plasticizer, solvent casting, bioavailability enhancement.

 


[PDF]  Viewed: 949  Downloaded: 175
  • Call for paper
    Call for paper

    American Journal of Pharmacy and Health Research (AJPHR) is a peer-reviewed, monthly official international journal allowing access to abstracts and full-text.

  • Email & SMS Alerts
    Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics
    Article Statastics

    American Journal of Pharmacy and Health Research (AJPHR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission
    Online Submission

    American Journal of Pharmacy and Health Research (AJPHR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter