ISSN 2321–3647
Sun, 19 Nov 2017

Extractive Spectrophotometric Methods for the Determination of Racecadotril in Pure and Pharmaceutical Formulations

Lanka Venkateswara Rao1*, Surreddy Vijaya Mani Vardhan2, Rambabu Chintala3

1*Department of Chemistry, D.M.S.S.V.H .College of Engineering, Machilipatnam, AP, India.

2Department of Biochemistry, K.U.Dr.MRAR  P.G. Centre, Nuzvid, AP, India.

3Department of Chemistry,Acharya Nagarjuna University, Guntur, AP, India.

 


ABSTRACT

Two sensitive extractive spectrophotometric methods have been developed and validated for the estimation of Racecadotril in pure and pharmaceutical dosage forms. The developed methods are based on the formation of colored ion-association complex of drug with Tropaeolin  ooo[TPooo] and Alizarin  red-s  [ARS] extractable in chloroform. The optimum conditions such as effect of concentration of dyes, pH etc on color development have been established for these methods The extracted complexes showed absorbance maxima at 482 and 420nm for these developed methods. Beer’s law is obeyed in the concentration ranges between 8-40µg/ml for the two methods respectively. These newly developed methods can be applied for the determination of other drugs in commercial capsules and results of analysis were validated statistically in accordance with ICH guidelines.

Keywords: Racecadotril, Spectrophotometric methods, Tpooo,ARS, Chloroform.


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