ISSN 2321–3647
Sun, 19 Nov 2017

Design of Medicated Cream for Scalp Infections

Purushotham K. Rao1, Niranjan GV2, Saran Solleti3,Prashanth Sagre4, SK Patil 4, Muntasibalikhan1.

1. H.K.E.S’s College of pharmacy (M. R. Medical College Campus), Gulbarga. K.S. India.

2. Director. CDC, Rajiv Gandhi University of Health Services, Karnataka, Bangalore, K S. India

3. Laurentian university, Sudbury, Ontario, Canada.

4. Dept. Of Dermatology, MR Medical College and General Hospital, Gulbarga, K.S. India


Psoriasis is most frequently affects the skin of the elbows, knees, scalp, lumbosacral areas. It is the typical lesion well-demarcated, pink to salmon-colored plaque covered by loosely adherent scales that are characteristically silver white in color. Several topical therapies are available for the treatments of Scalp psoriasis like emollients, keratolytics, corticosteroids, tar, anthralin, vitamin D analogues and retinoids. .Currently available medications such as ointments and solutions are often greasy, sticky, odorous, difficult to apply, require frequent application, and are expensive causes poor patients compliance. In proposed work it is planned to prepare cream formulations of non-greasy and water removable, and improve patient’s compliance. This cream is o/w emulsion based formulation contain suitable combination of oil phase and aqueous phase along with preservatives, was prepared and subjected to various physiochemical parameters like drug content, pH, spreadability, tube extrudability, viscosity and IR studies. In-vitro drug release was carried out in phosphate buffer (pH 7.4) and compared with marketed formulation. Stability studies of formulation were also done at ambient temperature (30oC&40 oC) for the period of six months as per ICH guidelines. The formulations were subjected for primary skin irritation test in rabbits, guinea pigs, and healthy human volunteers for 72 hours and observed for any skin rashes, inflammation, itching, or redness. Drug content, pH, Spreadability, Tube extrudability of the formulation was found to be 95.47%, 7.2,, 96.14% respectively. From rheogram it is concluded that formulation shows pseudoplastic flow property. From our study it is revealed that salicylic acid  cream formulation should be useful for treatment of scalp psoriasis.

Keywords: Psoriasis, salicylic acid cream

[PDF]  Viewed: 4566  Downloaded: 133
  • Call for paper
    Call for paper

    American Journal of Pharmacy and Health Research (AJPHR) is a peer-reviewed, monthly official international journal allowing access to abstracts and full-text.

  • Email & SMS Alerts
    Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics
    Article Statastics

    American Journal of Pharmacy and Health Research (AJPHR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission
    Online Submission

    American Journal of Pharmacy and Health Research (AJPHR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter