ISSN 2321–3647
Sun, 19 Nov 2017

Anti-diabetic Efficacy of Dietary Vegetable Mixtures in Alloxan Induced Diabetic Guinea Pigs.

Nwafor Arthur1, Akunneh-Wariso Chris C*1, Ojeka Sunday Ogbu1, Agbai Emmanuel Onuka2

1.Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, PMB 5323, Choba, Port Harcourt;

2.Department of Physiology, Faculty of Basic Medical Sciences, Madonna University, PMB 407 Ihiala, Elele Campus, Rivers State.


The effect of Nigerian dietary vegetable mixtures composed of Vernonia amygdalina, Ocimum gratissimum, Gongronema latifolium, Solanum melongena, Phyllanthus amarus, and Piper nigrumas acclaimed as potent anti-hyperglycaemic agents were evaluated in accordance with local finished medicine products and practices in alloxan-induced diabetic guinea pigs. Blood glucose level analysis was used as diabetic indices. Taken together, the results of the present study, suggests that the strong cooperative additive/synergistic effects of the dietary vegetable mixtures (50/50/50) significantly (p<0.05) with reference to the base value ameliorated alloxan-induced elevated blood glucose level by 24% to 26% after 14 days when compared with that of the positive control (glibenclamide) of 20% or negative control (normal saline) of 41.6%. The demonstration in the present study of the anti-hyperglycaemic activities of the dietary vegetable mixtures is in resonance with its local application and may have important clinical implications in reducing health risks, specifically, type 2 diabetes mellitus and its complications.

Keywords: Diabetes, dietary vegetables, phytochenical/antioxidants, micronutrients, blood glucose

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