ISSN 2321–3647
Sun, 19 Nov 2017

Current updates on self nanoemulsifying drug delivery system and in vitro in vivo correlation of Probucol

Md. Habban Akhter1*, Govind Mohan1, Ayaz Ahmad1, Rachna2

1 NIMS Institute of Pharmacy, NIMS University, Jaipur, India.

2E4e Healthcare Pvt. Ltd. H-33 Sec-62, Noida.


ABSTRACT

The poor solubility is major drawback in the path of oral bioavailability. The oral bioavailability now a day is being enhanced via different technology. In which formulation of self nanoemulsified system proved to be highly significant in terms of improving oral bioavailability. Self nanoemulsifying drug delivery system is an isotropic mixture of natural or synthetic oils, surfactants, cosurfactants and solvents etc. Under gentle agitation in the intestinal tract this system forms fine oil-in water (o/w) microemulsion prior to absorption and thus dissolution are not a rate limiting step. The current review outlines current updates on self nanoemulsifying drug delivery system and in vitro in vivo correlation of Probucol. Many formulations based on lipid drug delivery was successfully marketed under the trade name of Neoral® (cyclosporine, Novartis), Ritonavir (Norvir®, Abbott laboratories), Fortovase (Saquinavir, Hoffmann‐La Roche lnc.), Agenerase (Amprenavir, GlaxoSmithKline), lipirex (Fenofibrate, Sanofi‐ Aventis).

Keywords: self nanoemulsifying drug delivery system, bioavailability, probucol, in vitro in vivo correlation.


[PDF]  Viewed: 1002  Downloaded: 131
  • Call for paper
    Call for paper

    American Journal of Pharmacy and Health Research (AJPHR) is a peer-reviewed, monthly official international journal allowing access to abstracts and full-text.

  • Email & SMS Alerts
    Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics
    Article Statastics

    American Journal of Pharmacy and Health Research (AJPHR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission
    Online Submission

    American Journal of Pharmacy and Health Research (AJPHR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter