ISSN 2321–3647
Sun, 19 Nov 2017

Evaluation of Protective Potential of Green Tea on Experimentally Induced Cardiotoxicity and Nephrotoxicity In Rats

Ayaz Ahmad1,*, Gyas Khan2, Sonu Sherma3

1.School of Pharmacy and Medical Sciences, Singhania University, Pacheri Bari, Jhunjhunu, Rajasthan, 333515. India

2.Jazan University, kingdom of Saudi Arabia.

3.Nims Institute of pharmacy, Nims University Shobha nagar, Jaipur.


ABSTRACT

Green tea extract (GTE) having so many flavonoid that protect doxorubicin induced cardiotoxicity and nephrotoxity in rats. A single dose of Doxorubicin (20 mg/kg i.p) on 29th day of treatment produced cardiotoxicity. A single dose of cisplatin (6 mg kg−1) was used to induce nephrotoxicity. Wistar Albino rats weighing between 150-200 g were distributed into eight groups comprising of eight animals in each group. Thiobarbituric acid reactive substances (TBARS), GSH, Superoxide dismutase (SOD), and Catalase (CAT) were estimated in heart tissue Reduced glutathione (GSH), Lactate dehydrogenase (LDH), Serum glutamate oxaloacetate (SGOT) and Creatinine phosphokinase (CPK) were estimated in blood. Histopathological studies were performed for the heart tissue of all the groups. DOX induced high serum levels of LDH, CPK and SGOT were reduced while GSH was increased significantly by GTE administration as compared to DOX receiving rats. Pretreatment with GTE ameliorated the cardiac content of GSH, SOD and CAT activities where as MDA level decreased significantly. Scr (serum creatinine) and BUN (blood urea nitrogen) were also estimated. The results support the antioxidant properties of GTE, which indicate cardioprotective role against Doxorubicin (DOX) induced cardiotoxity and nephroprotective role against cisplatin induced nephrotoxicity and its importance as adjuvant therapy in cancer management.

Keywords: Green tea extract, Doxorubicin, cisplatin, Antioxidants, Lipid peroxidation.


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