ISSN 2321–3647
Sun, 19 Nov 2017

Quantitative Estimation of Single Component Eperisone as API and in Tablet Dosage form using U.V. Spectrophotometry

 

Bharat Jhanwar1*, Sourabh Jain1

1.Department of Quality Assurance, Lachoo Memorial College of Science and Tech, Sector-A, Shastri Nagar, Jodhpur (Raj)


 

ABSTRACT

U.V. spectrophotometric method for estimation of Eperisone hydrochloride as individual and in tablet formulation using graphical extrapolation method has been developed. Methanol was selected as solvent for estimation at 258 nm. Linearity was followed in the range of 2.5-17.5 mg/ml with correlation coefficient of 0.997. Detection limit and quantitation limit were found to be 0.082 mg/ml and 0.22 mg/ml .Developed method has followed all the criteria for validation as per ICH norms and found to be accurate, precise, reproducible and sensitive with negligible excipients interference. Accuracy of the developed was assessed using spiking technique on available tablet dosage forms. Results obtained greater than 98% meant good accuracy of method for analysis in any dosage form.

Keywords: Eperisone hydrochloride, Graphical method, Methanol, Recovery, Validation.


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